MPSV Labs LLP • PreSynth Solutions Platform

PreSynth Standardized Anhydrous Solutions

Eliminate moisture-induced batch failures, uncontrolled dissolution heat, and dangerous compressed gas handling. Under the PreSynth line, MPSV Labs LLP delivers ultra-pure, standardized solutions of Zinc Chloride, Hydrogen Chloride, and Reactive Alkylamines across validated ethereal and green solvent matrices.

Explore PreSynth Catalog (19 Products)
100%
Dosage Ready
Closed loop accessories enabled
< 500 ppm
KF Moisture
Karl Fischer validated
1.0 - 4.0 M
Strictly Titrated
Nominal potency ±0.2M
2-MeTHF
Green Platforms
Renewable ethereal solvent
Safety & Operational Excellence

Industrial Bottlenecks Eliminated

Why process chemistries and chemical production facilities depend on MPSV PreSynth ready-to-dose solutions:

Deliquescent Solids

Atmospheric Degradation

Solid ZnCl₂ rapidly absorbs ambient air humidity, turning into an unweighable, corrosive sludge that ruins stoichiometric accuracy.

PreSynth Fix: Pre-dissolved in anhydrous ether, 2-MeTHF, or THF; inert gas blanketing.

Exothermic Runaways

Dangerous Heats of Solution

Dissolving dry salts or gas sparging releases intense heat, necessitating prolonged cooling cycles and risking solvent flash-boil.

PreSynth Fix: Direct closed-loop liquid charging without temperature surges.

Toxic Gas Sparging

Cylinder & Scrubber Hazards

Handling pressurized HCl or Methylamine gas creates severe operator hazards, pipe corrosion, non-linear dosing, and heavy scrubber loads.

PreSynth Fix: Standardized titrated solutions up to 4.0M in Dioxane, CPME, THF, or EtOAc.

Catalyst Poisoning

Yield Drops & Quenching

Trace moisture quenches expensive organolithium/Grignards and deactivates costly Pd/Ni catalysts in Negishi cross-couplings.

PreSynth Fix: Maximizes catalytic turnover (TON) & batch yield.
Standardized Portfolio

PreSynth Anhydrous Solutions Catalog (19 Reagents)

All lots tested by Karl Fischer titration & titrated for molarity
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Showing all 19 solutions
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Looking for PreSynth Anhydrous Reaction Solvents (THF, Toluene, EDC, Dioxane)?
Explore PreSynth Solvents Catalog
Reagent Name & Formula CAS Number Molarity / Strength Solvent Matrix Moisture Limit Key Advantage Inquiry
Zinc Chloride 1.0 Molar Solution in Tetrahydrofuran
ZnCl₂
7646-85-7 1.0 M Tetrahydrofuran (THF) < 500 ppm Standard DMF baseline for Negishi cross-couplings
Zinc Chloride 1.9 Molar Solution in 2-Methyltetrahydrofuran
ZnCl₂
7646-85-7 1.9 M 2-Methyltetrahydrofuran (2-MeTHF) < 400 ppm Biomass solvent; high concentration cuts reactor volume & VOCs
Zinc Chloride 1.0 Molar Solution in Diethyl Ether
ZnCl₂
7646-85-7 1.0 M Diethyl Ether (Et₂O) < 350 ppm Low-temperature stereoselective additions & easy stripping
Mono Methyl Amine 2.0 Molar Solution in Tetrahydrofuran
CH₃NH₂
74-89-5 2.0 M Tetrahydrofuran (THF) < 400 ppm Safe, closed-system amide synthesis without toxic gas feeding
Mono Methyl Amine 2.0 Molar Solution in Isopropyl Alcohol
CH₃NH₂
74-89-5 2.0 M Isopropyl Alcohol (IPA) < 400 ppm Cost-effective nucleophilic aminations in polar protic media
Dimethyl Amine 2.0 Molar Solution in Tetrahydrofuran
(CH₃)₂NH
124-40-3 2.0 M Tetrahydrofuran (THF) < 400 ppm Direct dimethylamination for pharma APIs & agrochemicals
Dimethyl Amine 2.0 Molar Solution in Isopropyl Alcohol
(CH₃)₂NH
124-40-3 2.0 M Isopropyl Alcohol (IPA) < 400 ppm Mild, non-pressurized nucleophilic substitutions
Ethyl Amine 2.0 Molar Solution in Tetrahydrofuran
C₂H₅NH₂
75-04-7 2.0 M Tetrahydrofuran (THF) < 400 ppm Precise N-ethylations and heterocyclic ring constructions
Ethyl Amine 70% Solution in Water
C₂H₅NH₂
75-04-7 70% w/w Water (H₂O) Aqueous Bulk industrial intermediate synthesis
Hydrogen Chloride 4.0 Molar Solution in 1,4-Dioxane
HCl
7647-01-0 4.0 M 1,4-Dioxane < 300 ppm Standard benchmark reagent for rapid N-Boc deprotection
Hydrogen Chloride 3.0 Molar Solution in Cyclopentyl Methyl Ether (CPME)
HCl
7647-01-0 3.0 M Cyclopentyl Methyl Ether (CPME) < 350 ppm High boiling point (106°C), non-peroxide forming green medium
Hydrogen Chloride 1.0 M Solution in Ethyl Acetate
HCl
7647-01-0 1.0 M Ethyl Acetate (EtOAc) < 350 ppm Non-ether solvent; facilitates immediate crystalline salt precipitation
Hydrogen Chloride 4.0 M Solution in Ethyl Acetate
HCl
7647-01-0 4.0 M Ethyl Acetate (EtOAc) < 350 ppm Non-ether solvent; facilitates immediate crystalline salt precipitation
Hydrogen Chloride 1.0 M Solution in Diethyl Ether
HCl
7647-01-0 1.0 M Diethyl Ether (Et₂O) < 300 ppm Rapid low-temperature cleavage of acid-sensitive protecting groups
Hydrogen Chloride 2.0 M Solution in Diethyl Ether
HCl
7647-01-0 2.0 M Diethyl Ether (Et₂O) < 300 ppm Rapid low-temperature cleavage of acid-sensitive protecting groups
Hydrogen Chloride 10% w/v Solution in Isopropyl Alcohol
HCl
7647-01-0 10% w/v Isopropyl Alcohol (IPA) < 400 ppm Reliable Fischer esterification & crystallization matrix
Hydrogen Chloride 3.0 Molar Solution in n-Butanol
HCl
7647-01-0 3.0 M n-Butanol < 400 ppm Selective high-temperature esterifications and cleavages
Hydrogen Chloride 1.0 Molar Solution in Acetic Acid
HCl
7647-01-0 1.0 M Acetic Acid < 300 ppm Specialized peptide synthesis & steroid modifications
Hydrochloric Acid 0.1N Volumetric Standard Solution
HCl
7647-01-0 0.1 N Aqueous Standard Volumetric QC titration standard
* Custom titers, mixed solvent blends (e.g. Toluene, MTBE, Hexanes), and private labeling available upon request. Target Molarity Tolerance: ±0.2M
Reaction Chemistry Platforms

High-Value Synthesis Platforms Enabled

Engineered specifically for active pharmaceutical ingredient (API) steps, stereoselective transformations, and sensitive organometallic cascades.

Platform 01

Stereoselective Lewis Acid Catalysis

PreSynth Zinc Chloride solutions provide clean coordination for diastereoselective aldol reactions, Friedel-Crafts acylations, and Negishi cross-coupling transmetalations without moisture poisoning.

Reagents: ZnCl₂ in 2-MeTHF, THF, Et₂O
Platform 02

Anhydrous Cleavage & Deprotection

Standardized anhydrous HCl in CPME and 1,4-Dioxane enables clean Boc, Trityl, and acetal deprotection without competing aqueous hydrolysis or chlorinated solvent hazards.

Reagents: HCl 1.0M - 4.0M in Dioxane / CPME / EtOAc
Platform 03

Controlled Nucleophilic Amination

Accurate molarity methylamine and dimethylamine solutions in THF provide stoichiometric amide couplings and SNAr displacements without toxic headspace venting.

Reagents: Alkylamines ~2.0M in THF / IPA
Containment Engineering

Closed-Loop Packaging & Dispensing Standards

Designed to ensure that reagents reach your reaction flask at the exact moisture titer certified at release.

LAB & PILOT SCALE

Septum Bottles

Multi-layer resealable septa enable repeated syringe and cannula transfers under positive nitrogen pressure without exposing the bulk reagent to atmospheric moisture or ambient oxygen.

250 mL
1.0 L
2.5 L
INTERMEDIATE & PLANT SCALE

Stainless Steel Cylinders

Equipped with dry-break quick-connect couplings, pressure relief devices, and dual liquid/vapor valves. Reagents are pressurized directly into reactor headspaces with zero operator exposure.

100 Litres (Dip-Tube Equipped)
BULK COMMERCIAL SUPPLY

GI / MS / Composite / HDPE Barrels

UN-certified galvanized iron (GI), mild steel (MS), fluoropolymer-lined composite, and high-density polyethylene (HDPE) drums (30 L – 200 L). Engineered with chemical-resistant barrier linings and dual-bung fittings for closed-loop inert transfer and automated diaphragm pump charging.

GI Barrels
MS Barrels
Composite Barrels
HDPE Drums